As we approach “the climate tipping point” and a host of interrelated and critical planetary thresholds, the seminar seeks to examine the environmental impacts of building sector activity and the agency of architects (and the building sector more broadly) in mitigating and potentially reversing the ecological and atmospheric impacts created through the building life cycle and its flows of material and energy. What if, instead of depleting our planet’s forests, peatlands, and wetlands, the making of buildings and cities could incentivize their restoration and enhance biodiversity while rebalancing socioeconomic inequity? As both the science and technical means of biospheric management evolve, concurrent innovations in bio-based and circular economic construction and associated methods of impact assessment offer the possibility for a new and powerful symbiosis between healthy ecosystems and convivial urban growth. In an era of big data, bioregional synergies can be analyzed and predicted through extrapolative methodologies using broad datasets and powerful computational models. But they must also be explored, tested, and implemented through empirical means, simultaneously, in regional ecosystems and the urban areas that would rely on them and provide critical feedback. Through a range of readings, analytical exercises, and material and assembly tests, the seminar engages advanced concepts and methods of regenerative design and construction and posits system change for global building.